It can affect any region that has hair but it usually involves, scalp and beard. It presents itself with small well demarcated bald patches with seemingly healthy skin below, with no scarring on skin. SYMPTOMS AND CLASSIFICATION OF ALOPECIA AREATA It shares genetic risk with autoimmune conditions like Diabetes Mellitus Type 1, Rheumatoid Arthritis and may accompany each other.It may be the only manifestation of Celiac disease.Ĭases with congenital Alopecia Areata are also noted.It has strong hereditary association.Its a non contagious disease. PRDX5 and STX17 genes expressed in the hair follicle are associated with Alopecia Areata. Genes associated with this disease have functions of controlling the activation and proliferation of regulatory T cells, cytotoxic T-Lymphocyte-Associated Antigen 4, InterLeukin-2, InterLeukin-2 receptor A, and Eos, and HLA. T-cell mediates inflamatory response around hair follicle which damages hair follicle.Įndogenous retinoids metabolic disorder plays a major role in its pathogenesis.Ītleast 129 various SNP are associated with this disease in genome.Ītleast 4 regions in genome are found to have these genes Its thought to be systemic autoimmune disorder affecting anagen hairfollicle.Its T-cell mediated inflamatory non scarring condition. Alopecia Areata Before treatment at Dr SHAH’s Homoeopathy Alopecia Areata After treatment at Dr SHAH’s Homoeopathy by Dr Deepan P Shah PATHOHENESIS AND GENETICS OF ALOPECIA AREATA Alopecia Areata is a systemic autoimmune disorder where autoantibodies are driven against anagen hair follicle.
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